Avtor/Urednik		Giannopoulou, Efstathia; Katsila, Theodora; Mitropoulou, Christina; Tsermpini, Evangelia Erini; Patrinos, George P.
Naslov		Integrating next-generation sequencing in the clinical pharmacogenomics workflow
Tip		članek
Vol. in št.		, št. Vol. 10
Leto izdaje		2019
Obseg		str. 1-6
ISSN		1663-9812 - Frontiers in pharmacology
Jezik		eng
Abstrakt		Pharmacogenomics has been recognized as a fundamental tool in the era of personalized medicine with up to 266 drug labels, approved by major regulatory bodies, currently containing pharmacogenomics information. Next-generation sequencing analysis assumes a critical role in personalized medicine, providing a comprehensive profile of an individual's variome, particularly that of clinical relevance, comprising of pathogenic variants and pharmacogenomic biomarkers. Here, we propose a strategy to integrate next-generation sequencing into the current clinical pharmacogenomics workflow from deep resequencing to pharmacogenomics consultation, according to the existing guidelines and recommendations.
Proste vsebinske oznake		clinical decision support tools clinical pharmacogenomics workflow orodja za podporo kliničnemu odločanju klinična farmakogenomika potek dela