Avtor/Urednik		Tsermpini, Evangelia Erini; Tsermpini, Evangelia Erini; Assimakopoulos, Konstantinos; Bartsakoulia, Marina; Iconomou, Gregoris; Merkouri Papadima, Eleni; Mitropoulos, Konstantinos; Squassina, Alessio; Patrinos, George P.
Naslov		Individualizing clozapine and risperidone treatment for schizophrenia patients
Tip		članek
Vol. in št.		Letnik 15, št. 1
Leto izdaje		2014
Obseg		str. 95-110
ISSN		1462-2416 - Pharmacogenomics
Jezik		eng
Abstrakt		Schizophrenia is a severe disorder that significantly affects the quality of life and total functioning of patients and their caregivers. Clozapine is the first atypical antipsychotic with fewer adverse effects and established efficacy. As a rule of thumb, risperidone is one of the most reliable and effective antipsychotics for newly diagnosed and chronic schizophrenics. Pharmacogenetic studies have identified genomic variants of candidate genes that seem to be important in the way a patient responds to treatment. The recent progress made in pharmacogenomics will improve the quality of treatment, since drug doses will be tailored to the special needs of each patient. In this article, we review the available literature attempting to delineate the role of genomic variations in clozapine and risperidone response in schizophrenic patients of various ethnicities. We conclude that pharmacogenomics for these two drugs is still not ready for implementation in the clinic.
Proste vsebinske oznake		genomic variations pharmacogenomics schizophrenia genomske variacije farmakogenomika shizofrenija