Avtor/Urednik		Žiberna, Klemen; Jež, Mojca; Jazbec, Katerina; Mali, Polonca; Rahne-Potokar, Urška; Rožman, Primož
Naslov		ABO blood group does not influence the level of anti-SARS-CoV-2 antibodies in convalescent plasma donors
Tip		članek
Leto izdaje		2022
Obseg		str. str.
ISSN		0041-1132 - Transfusion
Jezik		eng
Abstrakt		Background: The association of the ABO blood group with COVID-19 disease has been confirmed by several studies, with the blood group A patients being more susceptible and prone to a more severe clinical course of the disease. Additionally, several authors also addressed the association of ABO-types and the levels of anti-SARS-CoV-2 antibodies in convalescents, mostly supporting a theory that the non-O blood group convalescents present with higher levels of anti-SARS-CoV-2 antibodies. Study design and methods: Since previous findings were based on small convalescent cohorts, we quantified the anti-SARS-CoV-2 antibody levels in a total of 3187 convalescent plasma donors with three commercial serological and one standard neutralizing antibody test. The majority of donors had undergone a mild form of the disease and the median time of sampling was 66 days after diagnosis. Results: None of the antibody quantitation results showed any significant association with the ABO blood group types. The same result was evident in the subgroup of vaccinated individuals (n = 370) and the subgroups when stratified according to post-COVID-19 periods (0-60, 60-120, and 120-180 days). Conclusion: In conclusion, we found no evidence to confirm that the ABO blood group types influence the level of SARS-CoV-2 antibody response in COVID-19 convalescent plasma donors.
Proste vsebinske oznake		COVID-19 convalescent plasma SARS-CoV-2 antibodies humoral immunity rekonvalescentna plazma COVID-19 protitelesa SARS-CoV-2 humoralna imunost