Avtor/Urednik		Bagaria, Sanjay P.; Swallow, Carol; Suraweera, Harini; Raut, Chandrajit P.; Fairweather, Mark; Cananzi, Ferdinando; Quagliuolo, Vittorio; Grignani, Giovanni; Hompes, Daphne; Novak, Marko
Naslov		Morbidity and outcomes after distal pancreatectomy for primary retroperitoneal sarcoma
Tip		članek
Vol. in št.		, št. Vol. 28
Leto izdaje		2021
Obseg		str. 6882‐6889
ISSN		1068-9265 - Annals of surgical oncology
Jezik		eng
Abstrakt		Multi-visceral resection often is used in the treatment of retroperitoneal sarcoma (RPS). The morbidity after distal pancreatectomy for primary pancreatic cancer is well-documented, but the outcomes after distal pancreatectomy for primary RPS are not. This study aimed to evaluate morbidity and oncologic outcomes after distal pancreatectomy for primary RPS. Methods: In this study, 26 sarcoma centers that are members of the Trans-Atlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG) retrospectively identified consecutive patients who underwent distal pancreatectomy for primary RPS from 2008 to 2017. The outcomes measured were 90-day severe complications (Clavien-Dindo % 3), postoperative pancreatic fistula (POPF) rate, and oncologic outcomes. Results: Between 2008 and 2017, 280 patients underwent distal pancreatectomy for primary RPS. The median tumor size was 25 cm, and the median number of organs resected, including the pancreas, was three. In 96% of the operations, R0/R1 resection was achieved. The 90-day severe complication rate was 40 %. The grades B and C POPF complication rates were respectively 19% and 5% and not associated with worse overall survival. Administration of preoperative radiation and factors to mitigate POPF did not have an impact on the risk for the development of a POPF. The RPS invaded the pancreas in 38% of the patients, and local recurrence was doubled for the patients who had a microscopic, positive pancreas margin (hazard ratio, 2.0; p = 0.042). Conclusion: Distal pancreatectomy for primary RPS has acceptable morbidity and oncologic outcomes and is a reasonable approach to facilitate complete tumor resection.
Proste vsebinske oznake		sarkom retroperitonealni sarkom kirurško zdravljenje smrtnost sarcoma retroperitoneal sarcoma surgery morbidity