Avtor/Urednik		Žužek, Zala; Bolčina, Lara; Kump, Ana; Jovchevska, Ivana
Naslov		Repozicioniranje zdravil
Prevedeni naslov		Drug repurposing
Tip		članek
Vol. in št.		Letnik 73, št. 1
Leto izdaje		2022
Obseg		str. 23-30
ISSN		0014-8229 - Farmacevtski vestnik : strokovno glasilo slovenske farmacije
Jezik		slv
Abstrakt		Glioblastoma is the most common and lethal brain malignancy. Standard treatment consists of surgery, radiotherapy and chemotherapy, and results in life expectancy of 15 months after diagnosis. Due to the specific location of the tumor, designing new drugs is complicated and expensive. Drug repur- posing is an economic and time-saving way for identification of alternative treatment options. Nu- merous existing drugs whose initial purpose was not to treat cancer, have already proven successful against glioblastoma. For glioblastoma, attention is paid to antidiabetic drugs, antipsychotics and antiepileptics that can easily cross the blood-brain barrier. Studies show that adding the antidiabetic metformin or antiepileptic drug valproic acid to the standard glioblastoma therapy might prolong patient survival. However, the exact mechanisms of action should further be studied and possible interactions should be examined in order to avoid unnecessary complications and adverse effects.
Proste vsebinske oznake		CAR-T glioblastom imunoterapija glioblastoma metformin valproic