Avtor/Urednik		De Zuani, Marco; Lazničková, Petra; Tomašková, Veronika; Dvončová, Martina; Forte, Giancarlo; Stokin, Gorazd Bernard; Šrámek, Vladimir; Helán, Martin; Frič, Jan
Naslov		High CD4- to-CD8 ratio identifies an at- risk population susceptible to lethal COVID- 19
Tip		članek
Vol. in št.		Letnik 95, št. 3
Leto izdaje		2022
Obseg		str. 1-11
ISSN		1365-3083 - Scandinavian journal of immunology
Jezik		eng
Abstrakt		Around half of people with severe COVID-19 requiring intensive care unit (ICU) treatment will survive, but it is unclear how the immune response to SARS-CoV-2 differs between ICU patients that recover and those that do not. We conducted whole-blood immunophenotyping of COVID-19 patients upon admission to ICU and during their treatment and uncovered marked differences in their circulating immune cell subsets. At admission, patients who later succumbed to COVID-19 had significantly lower frequencies of all memory CD8+ T cell subsets, resulting in increased CD4-to-CD8 T cell and neutrophil-to-CD8 T cell ratios. ROC and Kaplan-Meier analyses demonstrated that both CD4-to-CD8 and neutrophil-to-CD8 ratios at admission were strong predictors of in-ICU mortality. Therefore, we propose the use of the CD4-to-CD8 T cell ratio as a marker for the early identification of those individuals likely to require enhanced monitoring and/or pro-active intervention in ICU.
Proste vsebinske oznake		COVID-19 CD4-to-CD8 ratio intensive care unit COVID-19 razmerje med CD4 in CD8 enota za intenzivno nego