Avtor/Urednik | Gonzalez-Rivas, Juan P.; Mechanick, Jeffrey I.; Infante-Garcia, María M; Medina-Inojosa, Jose Ramon; Pavlovska, Iuliia; Hlinomaz, Ota; Zak, Petr; Kunzová, Šárka; Nieto-Martinez, Ramfis; Stokin, Gorazd Bernard | |
Naslov | The prevalence of dysglycemia-based chronic disease in a European population - a new paradigm to address diabetes burden | |
Tip | članek | |
Vol. in št. | Letnik 27, št. 5 | |
Leto izdaje | 2021 | |
Obseg | str. 571-578 | |
ISSN | 1530-891X - Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists | |
Jezik | eng | |
Abstrakt | Objective: To determine the prevalence rate and associated risk factors for each stage of the Dysglycemia-Based Chronic Disease (DBCD) model, which 4 distinct stages and prompts early prevention to avert Diabetes and cardiometabolic complications. Methods: Subjects between 25 and 64 years old from a random population-based sample were evaluated in Czechia from 2013 to 2014 using a cross-sectional design. DBCD stages were: stage 1 "insulin resistance" (inferred risk from abdominal obesity or a family history of diabetes); stage 2 "prediabetes"(fasting glucose between 5.6 and 6.9 mmol/L); stage 3 "type 2 diabetes (T2D)" (self-report of T2D or fasting glucose s7 mmol/L); and stage 4 "vascular complications" (T2D with cardiovascular disease). Results: A total of 2147 subjects were included (57.8% women) with a median age of 48 years. The prevalence of each DBCD stage were as follows: 54.2% (stage 1); 10.3% (stage 2), 3.7% (stage 3); and 1.2% (stage 4). Stages 2 to 4 were more frequent in men and stage 1 in women (P < .001). Using binary logistic regression analysis adjusting by age/sex, all DBCD stages were strongly associated with abnormal adiposity, hypertension, dyslipidemia, and smoking status. Subjects with lower educational levels and lower income were more likely to present DBCD. Conclusion: Using the new DBCD framework and available metrics, 69.4% of the population had DBCD, identifying far more people at risk than a simple prevalence rate for T2D (9.2% in Czechia, 2013-2014). All stages were associated with traditional cardiometabolic risk factors, implicating common pathophysiologic mechanisms and a potential for early preventive care. The social determinants of health were related with all DBCD stages in alarming proportions and will need to be further studied. | |
Proste vsebinske oznake | bolezni srca in ožilja sladkorna bolezen t epidemiologija cardiovascular disease diabetes epidemiology |