Avtor/Urednik		Rades, Dirk; Cacicedo, Jon; Lomidze, Darejan; Al-Salool, Ahmed; Šegedin, Barbara; Grošelj, Blaž; Schild, Steven E.
Naslov		Prognostic value of preclinical markers after radiotherapy of metastatic spinal cord compression
Tip		članek
Vol. in št.		Letnik 14, št. 10
Leto izdaje		2022
Obseg		str. 2547-1-2547-11
ISSN		2072-6694 - Cancers
Jezik		eng
Abstrakt		For optimal personalization of treatment for metastatic spinal cord compression (MSCC), the patient’s survival prognosis should be considered. Estimation of survival can be facilitated by prognostic factors. This study investigated the prognostic value of pre-treatment preclinical markers, namely hemoglobin, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lactate dehydrogenase (LDH), and c-reactive protein (CRP), in 190 patients from two prospective trials who had poor or intermediate survival prognoses and were irradiated for MSCC with motor deficits. In addition, clinical factors including radiation regimen, age, gender, tumor type, interval from tumor diagnosis to MSCC, number of affected vertebrae, visceral metastases, other bone metastases, time developing motor deficits, ambulatory status, sensory function, and sphincter function were evaluated. On univariate analyses, NLR (p = 0.033), LDH (p < 0.001), CRP (p < 0.001), tumor type (p < 0.001), pre-radiotherapy ambulatory status (p < 0.001), and sphincter function (p = 0.011) were significant. In the subsequent Cox regression analysis, LDH (p = 0.007), CRP (p = 0.047), tumor type (p = 0.003), and ambulatory status (p = 0.010) maintained significance. In addition to clinical factors, preclinical markers may help in estimating the survival of patients irradiated for MSCC. Additional prospective trials are warranted.
Proste vsebinske oznake		metastatska kompresija hrbtenjače radioterapija prospektivne študije preživetje metastatic spinal cord compression radiotherapy prospective trials survival