Avtor/Urednik		Stolz, Bernadette J.; Käppler, Jakob Raphael; Markelc, Boštjan; Braun, Franziska; Lipsmeier, Florian; Muschel, Ruth J.; Byrne, Helen; Harrington, Heather A.
Naslov		Multiscale topology characterizes dynamic tumor vascular networks
Tip		članek
Vol. in št.		Letnik 8, št. 23
Leto izdaje		2022
Obseg		str. 2456-1-2456-15
ISSN		2375-2548 - Science advances
Jezik		eng
Abstrakt		Advances in imaging techniques enable high-resolution three-dimensional (3D) visualization of vascular net-works over time and reveal abnormal structural features such as twists and loops, and their quantification is an active area of research. Here, we showcase how topological data analysis, the mathematical field that studies the “shape” of data, can characterize the geometric, spatial, and temporal organization of vascular networks. We pro-pose two topological lenses to study vasculature, which capture inherent multiscale features and vessel connec-tivity, and surpass the single-scale analysis of existing methods. We analyze images collected using intravital and ultramicroscopy modalities and quantify spatiotemporal variation of twists, loops, and avascular regions (voids) in 3D vascular networks. This topological approach validates and quantifies known qualitative trends such as dynamic changes in tortuosity and loops in response to antibodies that modulate vessel sprouting; furthermore, it quantifies the effect of radiotherapy on vessel architecture.
Proste vsebinske oznake		radioterapija slikovne tehnike matematični modeli tumorji