Avtor/Urednik		Kiraly, Peter; Lavrič, Alenka; Vidović Valentinčič, Nataša; Jaki Mekjavić, Polona; Urbančič, Mojca; Ocvirk, Janja; Mesti, Tanja
Naslov		Choroidal thickening with serous retinal detachment in BRAF/MEK inhibitor-induced uveitis
Tip		članek
Vol. in št.		Letnik 10, št. 19
Leto izdaje		2022
Obseg		str. 6536-6542
ISSN		2307-8960 - World journal of clinical cases
Jezik		eng
Abstrakt		Immune checkpoint inhibitors have revolutionized the treatment of patients with unresectable metastatic malignant melanoma. In addition to systemic side effects, several usually mild ocular adverse effects have been reported. We report a case of rarely reported vision-threatening bilateral panuveitis with serous retinal detachment, thickened choroid, and chorioretinal folds associated with dabrafenib and trametinib targeted therapy for B-Raf proto-oncogene serine/threonine kinase (BRAF) mutant metastatic cutaneous melanoma. CASE SUMMARY A 59-year-old female patient with metastatic melanoma treated with dabrafenib and trametinib presented with blurry vision and central scotoma lasting for 3 d in both eyes. Clinical examination and multimodal imaging revealed inflammatory cells in the anterior chamber, mild vitritis, bullous multiple serous retinal detachments, and chorioretinal folds in both eyes. Treatment with dabrafenib and trametinib was suspended, and the patient was treated with topical and intravenous corticosteroids followed by oral corticosteroid treatment with a tapering schedule. One and a half months after the disease onset, ocular morphological and functional improvement was noted. Due to the metastatic melanoma dissemination, BRAF/mitogen-activated protein kinase inhibitors were reintroduced and some mild ocular adverse effects reappeared, which later subsided after receiving oral corticosteroids. CONCLUSION Patients on combination therapy with dabrafenib and trametinib may rarely develop severe bilateral panuveitis with a good prognosis. Further studies have to establish potential usefulness of ophthalmological examination for asymptomatic patients. Furthermore, appropriate guidelines for managing panuveitis associated with dabrafenib and trametinib should be established.
Proste vsebinske oznake		metastatski melanom kemoterapija zaviralci BRAF/MEK neželeni učinki na očeh metastatic melanoma treatment chemotherapy BRAF/MEK inhibitors ocular adverse effects