Avtor/Urednik | Osredkar, Joško; Fabjan, Teja; Kumer, Kristina; Tršan, Jure; Poljančič, Laura; Košir, Miha; Vovk, Pia; Snoj, Nada; Finderle, Petra; Možina, Hugon | |
Naslov | Comparison of ADVIA Centaur ultra-sensitive and high-sensitive assays for troponin I in serum | |
Tip | članek | |
Vol. in št. | Letnik 33, št. art. e00293 | |
Leto izdaje | 2022 | |
Obseg | str. 1-6 | |
ISSN | 2352-5517 | |
Jezik | eng | |
Abstrakt | Cardiac troponin I (cTnI) is a standard biomarker for the diagnosis of acute myocardial infarction (AMI). While older, ultra-sensitive cTnI (us-cTnI) assays use the 99th percentile as the reference threshold, newer high-sensitive cTnI (hs-cTnI) assays use the limit of detection or functional sensitivity instead. However, little has been done to systematically compare these two methods. The present study also served as a validation of hs-cTnI in our laboratory. Here, we compared the results obtained from the blood serum obtained from 8810 patients using the us-cTnI and the hs-cTnI assays run in tandem on the ADVIA Centaur XP analyser. We found that in 2279 samples the concentration of cTnI measured with the ultra-sensitive method was below the detection limit, while with the high-sensitive method, only 540 were below the detection limit. We also compared results from these assays with the ultimate diagnosis of a subset of individuals. The analysis of the results below cut-off with the ultra-sensitive method showed that this method would not detect 96 cases related to heart disorder. Overall, the main finding of our research is that hs-cTnI is the preferable option and is able to be deployed effectively in the laboratory setting. | |
Deskriptorji | Miokardni infarkt Akutni koronarni sindrom Klinična kemija | |
Proste vsebinske oznake | acute coronary syndrome myocardial infarction Troponin I verification verifikacija troponin I |