Avtor/Urednik		Bouvier, Anne-Marie; Primic-Žakelj, Maja; Jarm, Katja
Naslov		Differences in the management and survival of metastatic colorectal cancer in Europe. A population-based study
Tip		članek
Vol. in št.		Letnik 53, št. 5
Leto izdaje		2021
Obseg		str. 639-645
ISSN		1590-8658 - Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Jezik		eng
Abstrakt		The management regarding metastatic colorectal cancer throughout Europe is not well known. Aims: To draw a European comparison of the management and prognosis of metastatic colorectal cancers. Methods: Factors associated with chemotherapy administration were identified through logistic regressions. Net survival was estimated and crude probabilities of death related to cancer and other causes using a flexible cumulative hazard model. Results: Among the 13 227 patients with colorectal cancer diagnosed between 2010 and 2013 in cancer registries from 10 European countries, 3140 were metastatic. 62% of metastatic patients received chemotherapy. Compared to Spain, the related adjusted odds ratios ranged from 0.7 to 4.0 (P<0.001) according to country. The 3-year net survival by country ranged between 16% and 37%. The survival gap between countries diminished from 21% to 10% when adjusting for chemotherapy, age and sex. Geographical differences in the crude probability of death related to cancer were large for patients <70 or s80 years at diagnosis. Conclusion: Heterogeneity in the application of European guidelines partly explain these differences. General health between populations, accessibility to a reference centre, or provision of health care could also be involved. Further population-based studies are warranted to disentangle between these possible explanations.
Proste vsebinske oznake		rak debelega črevesa in danke metastatski rak register raka colorectal cancer metastatic cancer cancer data