Avtor/Urednik		Glavač, Damjan; Mladinić, Miranda; Ban, Jelena; Mazzone, Graciela L.; Sámano, Cynthia; Tomljanović, Ivana; Jezernik, Gregor; Ravnik-Glavač, Metka
Naslov		The potential connection between molecular changes and biomarkers related to ALS and the development and regeneration of CNS
Tip		članek
Vol. in št.		Letnik 23, št. 19
Leto izdaje		2022
Obseg		str. 1-18
ISSN		1422-0067 - International journal of molecular sciences
Jezik		eng
Abstrakt		Neurodegenerative diseases are one of the greatest medical burdens of the modern age, being mostly incurable and with limited prognostic and diagnostic tools. Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease characterized by the loss of motoneurons, with a complex etiology, combining genetic, epigenetic, and environmental causes. The neuroprotective therapeutic approaches are very limited, while the diagnostics rely on clinical examination and the exclusion of other diseases. The recent advancement in the discovery of molecular pathways and gene mutations involved in ALS has deepened the understanding of the disease pathology and opened the possibility for new treatments and diagnostic procedures. Recently, 15 risk loci with distinct genetic architectures and neuron-specific biology were identified as linked to ALS through common and rare variant association analyses. Interestingly, the quantity of related proteins to these genes has been found to change during early postnatal development in mammalian spinal cord tissue (opossum Monodelphis domestica) at the particular time when neuroregeneration stops being possible. Here, we discuss the possibility that the ALS-related genes/proteins could be connected to neuroregeneration and development. Moreover, since the regulation of gene expression in developmental checkpoints is frequently regulated by non-coding RNAs, we propose that studying the changes in the composition and quantity of non-coding RNA molecules, both in ALS patients and in the developing central nervous (CNS) system of the opossum at the time when neuroregeneration ceases, could reveal potential biomarkers useful in ALS prognosis and diagnosis.
Proste vsebinske oznake		amiotrofična lateralna skleroza geni, povezani z ALS neuroregeneration amyotrophic lateral sclerosis ALS-related genes neuroregeneration