Avtor/Urednik		Savšek, Lina
Naslov		Nova diagnostična merila za multiplo sklerozo
Prevedeni naslov		New diagnostic criteria for multiple sclerosis
Tip		članek
Vir		In: [Zbornik prispevkov] Ljubljana : Medicinski razgledi
Vol. in št.		Letnik 57, št. supl. 4
Leto izdaje		2018
Obseg		str. 5-9
Jezik		slv
Abstrakt		Multipla skleroza se kaže z raznoliko klinično sliko. Prva diagnostična merila, razvita z namenom, da olajšajo postavitev diagnoze, so bila objavljena že leta 1965. Sprva so se opirala le na ustrezno klinično sliko, kasnejše posodobitve in spremembe meril pa so dale pomen tudi slikovnim in drugim parakliničnim preiskavam. Tako so bila leta 2001 razvita McDonaldova merila za multiplo sklerozo, ki so pomenila precejšnjo poenostavitev predhodnih Poserjevih meril in so v ospredje postavila predvsem slikovno diagnostiko. Zadnja posodobitev teh meril iz leta 2017 ponovno vrača pomen likvorski diagnostiki, v radiološka merila pa na novo vključuje kortikalne in simptomatske lezije in poudarja pomen natančne diferencialne diagnostike. Cilj ostaja čim zgodnejša in natančnejša postavitev diagnoze multiple skleroze, brez zmanjšanja občutljivosti in natančnosti diagnoze. To bo bolniku omogočilo čim prejšnje ustrezno zdravljenje, ki preprečuje nastop pomembne funkcionalne oviranosti.Multiple sclerosis is a multifaceted disease. To allow for an accurate diagnosis, the first diagnostic criteria were established as early as 1965. Originally relying on the presence of a typical clinical presentation, the criteria evolved during the following years and decades with the addition of imaging and other paraclinical markers. The McDonald diagnostic criteria were first established in 2001, thus replacing the previous more complex Poser criteria. In these criteria and its following revisions, special emphasis was given to the imaging criteria for multiple sclerosis. The latest revisions of McDonald diagnostic criteria, published in 2017, reinstate the role of cerebrospinal fluid analysis, reconsider the value of imaging findings that were previously not included (cortical and symptomatic lesions), and articulate more clearly cautions about misdiagnosis and differential diagnosis. The goal remains to obtain a rapid and accurate diagnosis of multiple sclerosis without decreasing the sensitivity and specificity of the diagnosis and thus allowing appropriate patient treatment in hopes of reducing long-term functional disability.
Deskriptorji		Multiple sclerosis Multipla skleroza Diagnosis Diagnostika