Avtor/Urednik		Vičič, Vid; Kukec, Andreja; Kugler, Saša; Geršak, Ksenija; Osredkar, Joško; Pandel Mikuš, Ruža
Naslov		Assessment of Vitamin D status in Slovenian premenopausal and postmenopausal women, using total, free, and bioavailable 25-hydroxyvitamin D (25(OH)D)
Tip		članek
Vol. in št.		Letnik 14, št. 24, art. 5349
Leto izdaje		2022
Obseg		str. 12 str.
ISSN		2072-6643 - Nutrients
Jezik		eng
Abstrakt		The objective of our study was to evaluate vitamin D status and its predictors in Slovenian premenopausal and postmenopausal women. A cross-sectional study was carried out between 1 March 2021 and 31 May 2021. A total of 319 healthy women from the Central Slovenian region aged between 44 and 65 were recruited; 176 were included in the final analysis. The vitamin D status was determined by measuring the total 25-Hydroxycholecalciferol (25(OH)D) concentration, vitamin D binding protein (DBP), and albumin and calculating the bioavailable 25(OH)D and free 25(OH)D. For the calculation of bioavailable and free 25(OH)D, we developed a new online calculator. The Endocrine Society’s thresholds for vitamin D deficiency and insufficiency were used; 29.0% of premenopausal and 24.4% of postmenopausal subjects were found to be vitamin D deficient (total 25(OH)D < 50 nmol/L); 76.8% of the premenopausal and 61.7% of postmenopausal subjects were found to have insufficient levels (total 25(OH)D < 75 nmol/L). Premenopausal women had 11.8% lower total 25(OH)D, 32.2% lower bioavailable 25(OH)D, and 25.2% higher DBP than postmenopausal women. The most important predictors of vitamin D status were vitamin D supplementation and time spent in the sun. Contrary to similar studies, the vitamin D status in Slovenian postmenopausal women was significantly better than in premenopausal women. In postmenopausal women, the measurement of free or bioavailable 25(OH)D instead of the total 25(OH)D could be advantageous.
Deskriptorji		Vitamin D Menopavza
Proste vsebinske oznake		25(OH)D postmenopausal premenopausal bioavailable 25(OH)D free 25(OH)D online calculator cholecalciferol calcidiol menopause DBP po menopavzi pred menopavzo biorazpoložljiv 25(OH)D prosti 25(OH)D spletni kalkulator holekalciferol kalcidiol