| Avtor/Urednik | Shehu Kolnikaj, Tea; Herman, Rok; Janež, Andrej; Jensterle Sever, Mojca | |
| Naslov | Eating disorders in women with polycystic ovary syndrome
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| Tip | članek | |
| Leto izdaje | 2022 | |
| Obseg | str. str. | |
| ISSN | 2673-8392 | |
| Jezik | eng | |
| Abstrakt | Polycystic ovary syndrome (PCOS) is a heterogeneous, multifactorial disease that leads to menstrual and ovulatory irregularities, infertility, hyperandrogenism, and metabolic disturbances. It is recognized as the most prevalent endocrine/metabolic disorder in reproductive-aged women. Despite continuous research efforts, the unifying pathophysiological mechanisms that could explain the etiology of this complex disorder are still not fully understood. The interplay between genetic and epigenetic factors, mitochondrial dysfunction, altered protein and miRNA profiles, and environmental factors that also contribute to obesity lead to exaggerated gonadotropin-releasing hormone (GnRH) pulsatility with hypersecretion of luteinizing hormone (LH) and insulin resistance (IR). Compensatory hyperinsulinemia adds to increased ovarian androgen production and impaired oocyte development. The essential role of the frequent coexistence of mental disorders and polycystic ovary syndrome (PCOS) is being increasingly recognized in the management of PCOS patients since it influences the success of weight loss interventions. Patients frequently experience disrupted eating behaviors, evidenced by the high prevalence of eating disorders in this population. Therefore, assessment and potential modification of eating disorders and eating-related behavior might be especially relevant to improve obesity treatment outcomes in this population, which remains the most efficient causal treatment in PCOS patients with high metabolic risk. | |
| Proste vsebinske oznake | polycystic ovary syndrome eating disorders metabolic disturbances sindrom policističnih jajčnikov motnje prehranjevanja presnovne motnje |