Avtor/Urednik		Hoerner, M; Heller-Vitouch, C; Ziegler, C; Soeltz-Szoets, J
Naslov		Azithromycin in the treatment of chlamydial cervicitis and urethritis
Tip		članek
Vir		Acta Dermatovenerol Alp Pannon Adriat
Vol. in št.		Letnik 4, št. 3
Leto izdaje		1995
Obseg		str. 121-5
Jezik		eng
Abstrakt		In a first step, the efficacy and safety of azithromycin as compared to doxycycline in the treatment of uncomplicated chlamydial cervicitis were assessed in a randomized, open clinical study. 32 female patients were enrolled in the study and treated either with a single oral dose of 1 g azithromycin of with a conventional course of doxycycline 100 mg b.i.d. for 7 days. In a second step, an open prospective evaluation was carried out comprising another 37 patients (25 males, 12 females) with chlamydial urethritis and-or cervicitis. The infection was verified by a non-radioactive RNA:DNA hybridization test and - in case of the comparative study groups - confirmed by positive culture. In a first follow up control all patients - except one treated with azythromycin - turned out to be clinically and microbiologically cured. The exceptional case rather seemed to be due to reinfection than to therapeutic failure. Both antibiotics were tolerated well; mild gastrointestinal side effects were reported in rare cases only. Our study confirms that in the treatment of uncomplicated chlamydial cervicitis and-or urethritis a single dose of 1 g azythromycin is as effective as doxycycline 100 mg b.i.d. for 7 days.
Deskriptorji		CERVICITIS AZITHROMYCIN CHLAMYDIA TRACHOMATIS URETHRITIS DOXYCYCLINE CHLAMYDIA INFECTIONS RANDOMIZED CONTROLLED TRIALS