Avtor/Urednik		Čufer, T
Naslov		Vpliv lastnosti primarnega raka dojk na kraj in čas razsoja pri bolnicah z rakom dojk - stadijev I in II
Tip		monografija
Kraj izdaje		Ljubljanja
Založnik		Medicinska fakulteta
Leto izdaje		1995
Obseg		str. 78
Jezik		slo
Abstrakt		Our retrospective study performed on a group of 230 patients with breast cancer stage I and II was aimed to assess the influence of primary tumor features on the time and site of the first dissemination. The mean follow-up period was 123 months. The roles of tumor size, pathohistological type and grade of malignancy, axillary lymph node involvement and DNA ploidy were studied as possible new prognostic factors. We have found that the disease-free survival, i.e. the time to the occurence of the first dissemination, was statistically significantly influenced by tumor size, pathohistological type and grade of malignancy as well as by axillary lymph node involvement. The disease-free survival was statistically worse in patients with larger tumors, tumors of high-grade malignancy, and in patients with affected axillary lymph nodes. DNA ploidy was not found to exert a statistically significant influence on the disease-free survival, despite the slightly better 10-year survival results in patients with diploid tumors, as compared to those with aneuploid tumors (60 pct. vs. 53 pct. respectively). Therefore, DNA ploidy in our group of patients did not turn out to be a prognostically relevant indicator of reccurence. Among the studied features, only the size of tumor and axillary lymph node involvement were found to be independent prognostic factors of recurrence. Further, we have found that the site of the first dissemination significantly depended on the size and DNA ploidy of the primary tumor. In comparison with larger ones, tumors smaller Abstract truncated at 3200 characters.
Deskriptorji		BREAST NEOPLASMS NEOPLASM METASTASIS NEOPLASM STAGING SURVIVAL ANALYSIS DNA FLOW CYTOMETRY PLOIDIES