Avtor/Urednik		Artacho-Perula, E; Roldan-Villalobos, R
Naslov		Quantitative analysis of nuclear volume and size variability of breast samples
Tip		članek
Vir		Acta Stereol
Vol. in št.		Letnik 15, št. 2
Leto izdaje		1996
Obseg		str. 111-8
Jezik		eng
Abstrakt		Two stereological methods recently developed for the estimation of the mean volume of particles are applied to normal breast samples and to invasive ductal breast carcinomas with the aim to evaluate the efficiency of these unbiased estimates and to obtain a real size variability of the nuclei. Both volume-weighted and number-weighted mean nuclear estimates demonstrate a high capacity for differentiating between normal andpathological lesions. A good correlation between different estimates of the mean nuclear volume is found. The information concerning nuclear size variability reveals a significant incrase from normal to invasive ductal breast samples when the coefficient of variation of nuclear volume CVN(v) was derived from inependent estimates of number-weighted ('selector' method) and volume-weighted ('point-sampled intercepts' method) mean nuclear volume. The study that efficiency of the volume-weighted mean nuclear volume estimates was higher than that of the number-weighted ones.
Deskriptorji		BREAST NEOPLASMS HISTOLOGICAL TECHNIQUES PARTICLE SIZE CELL NUCLEUS