Avtor/Urednik		Petrovič, D; Keber, I; Zorc, M; Peterlin, B
Naslov		I/D polymorphism at the locus for ACE and apo A-I gene promoter polymorphism as risk factors for coronary artery disease in patients with familial hypercholesterolemia
Tip		članek
Vir		Pflugers Arch
Vol. in št.		Letnik 431, št. 6 Suppl 2
Leto izdaje		1996
Obseg		str. R197-8
Jezik		eng
Abstrakt		In our study we searched for an association between the insertion/deletion (I/D) polymorphism at the ACE locus as well as apo A-I promoter polymorphism and coronary artery disease (CAD) in patients with familial hypercholesterolemia (FH). 34 FH patients over 40 years were ascertained; 16 patients with CAD were compared with 18 patients without CAD. There was an excess of DD or ID genotype in FH patients with CAD (OR=4.9, CI=1.17-22.17; Fisher exact p=0.012), however, no association between G to A substitution in the promoter region of the apo A-I gene and CAD was found. Our results suggest that the DD/ID genotype at the ACE gene locus might be an important genetic risk factor for CAD in FH patients.
Deskriptorji		HYPERCHOLESTEROLEMIA, FAMILIAL POLYMORPHISM (GENETICS) PEPTIDYL-DIPEPTIDASE A APOENZYMES CORONARY DISEASE RISK FACTORS