Avtor/Urednik     Budihna, MV; Grebenc, H
Naslov     Racemic nicardipine and its (-) enantiomer dose-dependently inhibit intestinal absorption of digoxin in guinea-pig in vivo
Prevedeni naslov     Racemni nikardipin in njegov (-) enantiomer od doze odvisno zavirata črevesno absorpcijo digoksina pri morskem prašičku in vivo
Tip     članek
Vir     Farm Vestn
Vol. in št.     Letnik 47, št. 2
Leto izdaje     1996
Obseg     str. 221-5
Jezik     eng
Abstrakt     In the study of interaction between digoxin and nicardipine we tried to establish whether the inhibition of digoxin intestinal absorption by nicardipine and its enantiomers was dose dependent. In previous studies in guinea-pig in vivo using (+-), (+), (-) nicardipine it has been found that the inhibition of digoxin intestinal absorption by nicardipine depended upon optical activity of nicardipine. In the present study the dose dependent inhibition of enteral absorption of digoxin by nicardipine and its (-) enantiomer was found. By extrapolation determined ICS50 was 0.27 mg/ml and 0.36 mg/ml (=0.027 mg/I00 g and 0.036 mg/100 g body weight) for (+-) and (-) nicardipine, respectively.
Deskriptorji     INTESTINAL ABSORPTION
DIGOXIN
NICARDIPINE
STEREOISOMERS
GUINEA PIGS
ANIMALS, LABORATORY