Avtor/Urednik		Freeman, CR; Suissa, S; Shenouda, G; Vuong, T; Souhami, L; Pla, M; Podgoršak, EB; Pla, C
Naslov		Clinical experience with a single field rotational total skin electron irradiation technique for cutaneous T-cell lymphoma
Tip		članek
Vir		Radiother Oncol
Vol. in št.		Letnik 24, št. 3
Leto izdaje		1992
Obseg		str. 155-62
Jezik		eng
Abstrakt		Between October 1981 and December 1989, 44 patients with cutaneous T-cell lymphoma (CTCL) were treated with a single field rotational total skin electron irradiation (RTSEI) technique developed in the McGill University, Department of Radiation Oncology. Only 11 (25 percent) of the 44 patients had received no prior treatment. Three-quarters (33/44) had advanced (T3 or T4) disease. Complete responses were seen in 32/44 (73 percent) of patients (91 percent T2, 71 percent T3 and 58 percent T4), but only 3/11 (27 percent) of patients with T2 disease and 3/21 (14 percent) of patients with T3 disease remain in continuous complete remission in the skin, after median intervals of 58 and 35 months, respectively. Median cause-specific survival for the whole group is 43 months and survival at 5 years is 38 percent. Survival was significantly better for patients with T2 disease than for patients with T3 disease (relative risk 4.3; 95 percent CI 1.4-13.2) and patients with T4 disease (relative risk 3.1; 95 percent CI 0.8-12.1). The RTSEI technique used at McGill has depth-dose characteristics and photon contamination similar to other commonly used TSEI techniques. It is relatively simple and provides a homogenous dose distribution over the entire skin surface in a short treatment time. Results of treatment are similar to those obtained with other techniques. For T2 disease, TSEI is an effective treatment modality with a possibility of long-term tumor control. For more advanced disease, more aggressive treatment, which may include TSEI, is necessary.
Deskriptorji		LYMPHOMA, T-CELL, CUTANEOUS RADIOTHERAPY, HIGH-ENERGY SKIN NEOPLASMS WHOLE-BODY IRRADIATION ADULT AGED AGED, 80 AND OVER COHORT STUDIES LYMPHOMA, T-CELL, CUTANEOUS MIDDLE AGE RADIOTHERAPY DOSAGE RETROSPECTIVE STUDIES ROTATION SKIN NEOPLASMS SURVIVAL RATE