| Avtor/Urednik | Lešničar, Hotomir; Šmid, Lojze; Zakotnik, Branko | |
| Naslov | Pomen stopnje diferenciranosti tumorjev in trajanja obsevalnega zdravljenja pri zgodnjem karcinomu glasilk | |
| Prevedeni naslov | The influence of tumor diifferentitation and overall treatment time in irradiated early glottic cancer | |
| Tip | članek | |
| Vir | Med Razgl | |
| Vol. in št. | Letnik 35, št. Suppl 6 | |
| Leto izdaje | 1996 | |
| Obseg | str. 181-7 | |
| Jezik | slo | |
| Abstrakt | One hundred and sixty patients with stage T1No or T2NO squamous cell carcinoma with histopathological grading findings were treated by continuous course radiotherapy. Ten-year recurrence free survival time was significantly better in tumor stage T1 patients and in patients with treatment time less than 48 days. There was no significant difference in recurrence free survival time between the different tumor differentiation groups. In the joint group of moderately and poorly differentiated tumors a statisticaly better recurrence free survival time was found in patients with overall treatment time less than 48 days. Overall treatment time of less or equal to 48 days resulted in better recurrence free survival time for both tumor stages. On the contrary, the opposite influence of overall treatment time of less or equal to 47 dayz on recurrence free survival time was established in patients with well differentiated tumors. Our results suggest that well differentiated early glottic cancer should be treated with conventional fractionation, while moderately and poorly differentiated tumors would benefit from accelerated and/or hyperfractionated radiotherapy. | |
| Izvleček | Med 160 bolniki, ki so bili primarno obsevalno zdravljeni zaradi zgodnjega karcinoma glasilk stadija T1No ali T2NO, je bila poleg histološke slike ploščatoceličnega karcinoma ugotovljena tudi stopnja diferenciacije tumorjev. Delež desetletnega preživetja brey ponovitve bolezni je bil značilno boljši pri bolnikih s tumorji stadija T1 in pri tistih bolnikih, pri katerih skupni čas obsevanja ni presegal 48 dni. Razlika v dolžini preživetja brey ponovitve bolezni med posameznimi skupinami glede na stopnjo diferenciacije tumorja ni bila značilna. Pri bolnikih s srednje in/ali slabo diferenciranimi tumorji smo ugotovili daljše preživetje brez ponovitve bolezni pri tistih bolnikih, pri katerih je obsevanje trajalo 48 dni ali manj. Nasprotno pa se je pri bolnikih z dobro diferenciranimi tumorji izkazalo, da je bil delež 10-letnega preživetja brez ponovitve bolezni pri bolnikih obsevanih v skupnem času, daljšem od 47 dni, celo značilno boljši. Naši rezultati govore v prid konvencionalnega razdeljevanja celotne tumorske doze na posamezne doze pri dobro diferenciranih tumorjih in uporabo akceleriranih režimov obsevanja predvsem pri srednje in slabo diferenciranih začetnih karcinomih glasilk. | |
| Deskriptorji | LARYNGEAL NEOPLASMS GLOTTIS NEOPLASM STAGING SURVIVAL RATE |