Avtor/Urednik		Cerar, A; Dolenc-Stražar, Z; Bartenjev, D
Naslov		Infantile hemangioendothelioma of the liver in a neonate
Tip		članek
Vir		Am J Surg Pathol
Vol. in št.		Letnik 20, št. 7
Leto izdaje		1996
Obseg		str. 871-6
Jezik		eng
Abstrakt		The study documents the immunohistochemical features of a case of infantile hemangioendothelioma (IHE) of the liver, which was found incidentally at autopsy in a 44-day-old girl. A precardial apical systolic murmur and hepatomegaly were found on day 4 of life. The tumor was multifocal and histologically composed of vascular channels lined by endothelial cells that were positive for von Willebrand factor, CD31, vimentin, adn Ulex europaeus agglutinin 1, and that were invested in a continous basement membrane (BM) on the antiluminal border. The endothelial cells, especially in the region of intravascular buds, showed intracytoplasmic synthesis of BM components (laminin and collagen IV). Inderlying the endothelial cells were cells with cytoplasm that was positive for alpha-smoooth muscle actin and antimuscle actin and negative for desmin, and that were enveloped with BM. The immunophenotype, appearance, and location of these cells are characteristic of pericytes. We found neither signs of endocrine secretion nor hepatitis B virus in the tumor tissue. The appearance of this tumor in the neonatal period supports a fetal origin of IHE.
Deskriptorji		HEMANGIOENDOTHELIOMA LIVER NEOPLASMS IMMUNOHISTOCHEMISTRY LAMININ VIMENTIN CELL ADHESION MOLECULES BASEMENT MEMBRANE ACTINS ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC VON WILLEBRAND FACTOR