Avtor/Urednik		Starc, V; Yellin, EL; Nikolič, SD
Naslov		Viscoelastic behavior of the isolated guinea pig left ventricle in diastole
Tip		članek
Vir		Am J Physiol
Vol. in št.		Letnik 271, št. 4 Pt 2
Leto izdaje		1996
Obseg		str. 1314-24
Jezik		eng
Abstrakt		To determine left ventricular (LV) viscoelastic properties during acute volume changes, the relaxation of LV pressure (2-Fr, Millar) at steady LV volume after a known volume change was measured in 14 isolated guinea pig left ventricles arrested in diastole. The left ventricle was loaded and unloaded by manual injection and withdrawal of saline in 10 x 0.1-ml steps, controlling the steadiness of LV volume by measuring LV major and minor diameters (ultrasonic crystals). Cyclic stepwise volume loading and unloading resulted in a hysteresis loop, the complexity of which was caused by stress relaxation at each steady volume. With the use of linear regression analysis, the gross elastic effect of the pressure signal was separated from the viscoelastic part, decomposed into the fast and the slow component with time constants of relaxation equal to 1 and 20 s, respectively. The amplitudes of the fast and the slow component showed that 1) stress relaxation is more expressed at higher LV volume and 2) it is asymmetric, i.e., it is well expressed during volume loading and almost absent during volume unloading. Both suggest that viscoelasticity of passive myocardium is not quasilinear, when the left ventricle is subjected to aperiodic volume loading to a high LV volume. The asymmetric viscoelastic behavior is consistent with the hypothesis of extracellular fluid filtration.
Deskriptorji		VENTRICULAR FUNCTION, LEFT BLOOD VOLUME DIASTOLE ECHOCARDIOGRAPHY ELASTICITY GUINEA PIGS MANOMETRY MODELS, BIOLOGICAL PRESSURE VISCOSITY