Avtor/Urednik		Poljak, Mario; Gale, Nina; Kambič, Vinko
Naslov		Human papillomaviruses: a study of their prevalence in the epithelial hyperplastic lesions of the larynx
Tip		članek
Vir		Acta Otolaryngol Suppl (Stockh)
Vol. in št.		, št. Suppl 527
Leto izdaje		1997
Obseg		str. 66-9
Jezik		eng
Abstrakt		This study investigated the prevalence of human papillomavirus (HPV) infection in various laryngela epithelial hyperplastic lesions using the Kambi; classification from simple hyperplasia to invasive squamous cell carcinoma. For detection of HPV infection polumerase chain reaction (PCR) with 3 different HPV consensus primer sets and in sity hybridization were used. The presence of the HPV DNA was detected in only 2 of the 88 specimens tested: HPV type 6 was detected in 1 case of simple hyperplasia and HPV type 15 in 1 case of invasive squamous cell carcinoma. In conclusion, our study suggests that most laryngeal epithelial hyperplastic lesions are not associated with HPV infection and that other pathogenic mechanisms are more important in the etiology of these lesions.
Deskriptorji		LARYNGEAL DISEASES HYPERPLASIA PAPILLOMAVIRUS, HUMAN BIOPSY POLYMERASE CHAIN REACTION