Avtor/Urednik		Kek, Anita
Naslov		Zgodnje funkcijske in morfološke spremembe arterijske stene pri sladkorni bolezni
Prevedeni naslov		Early functional and morphologic changes of arterial wall in diabetes
Tip		članek
Vir		Med Razgl
Vol. in št.		Letnik 35, št. 3
Leto izdaje		1996
Obseg		str. 309-36
Jezik		slo
Abstrakt		Diabetes mellitus is an important risk factor for atherosclerosis. The aim of this study was, first, to determine whether young patients with insulin-dependent diabetes mellitus display atherosclerotic changes at the stage when clinical signs of vascular disease have not yet developed, and, second, to identify the factors accelerating atherogenesis. New high-resolution ultrasound methods allow for the detection of early pathological changes of peripheral arteries. Changes in the blood flow and the diameter of brachial artery occurring during reactive hyperemia and after the administration of sublingual glyceril trinitrate were studied. In addition, the intima-media thickness of three different segments of carotid arteries was measured. Early functional and morphologic changes indicating accelerated atherogenesis were found to be present in young insulin-dependent diabetes mellitus patients. Functional disturbances (impairment of peripheral arteries flow-mediated dilation due to endothelial dysfunction) in insuline-dependent diabetes mellitus occur before morphologic changes have become apparent. Furthermore, there is a direct correlation between functonal and morphologic changes of the arterial wall.
Izvleček		Sladkorna bolezen je pomemben dejavnik tveganja za aterosklerozo. V raziskavi smo želeli ugotoviti, ali imajo mladi bolniki s sladkorno boleznijo po nekaj letih trajanja sladkorne bolezni, ko še nimajo kliničnih znakov žilnih bolezni, že prisotne določene funkcijske in morfološke spremembe v steni perifernih arterij. Merili smo sposobnost razširitve brahialne arterije med provokacijskimi testi (med hiperemijo, po gliceriltrinitratu) in debelino intime-medije karotidnih arterij. Ugotovili smo, da imajo mladi bolniki s sladkorno boleznijo po nekaj letih trajanja sladkorne bolezni že funkcijske in morfološke spremembe, ki kažejo na pospešeno aterogenezo. Funkcijske motnje (manjša sposobnost razširitve perifernih arterij zaradi endotelijske disfunkcije) nastanejo pri sladkorni bolezni pred vidnimi morfološkimi spremembami. Hkrati so funkcijske in morfološke spremembe v steni arterij tesno povezane.
Deskriptorji		ATHEROSCLEROSIS DIABETIC ANGIOPATHIES BRACHIAL ARTERY CAROTID ARTERY, COMMON ADULT CASE-CONTROL STUDIES BLOOD FLOW VELOCITY NITROGLYCERIN