Avtor/Urednik     Battelino, Tadej; Goto, Masakatsu; Zeller, W Patrick
Naslov     Dexamethasone attenuates hypoglycemia in ten day old rats treated with TNF alpha
Tip     članek
Vir     Res Commun Mol Pathol Pharmacol
Vol. in št.     Letnik 92, št. 2
Leto izdaje     1996
Obseg     str. 149-54
Jezik     eng
Abstrakt     Hypoglycemia during septic shock is a common and life-threatening sign in the newborn. TNFalpha is an important cytokine in endotoxic shock. The present study was performed to investigate if TNFalpha induces hypoglycemia and if dexamethasone ameliorates the TNFalpha effects in 10 day old rats. TNFalpha induced hypoglycemia and lactacidemia without altering plasma insulin concentration in 10 day old rats. TNFalpha increased GLUT1 mRNA abundance in brain, liver, muscle and fatty tissue, and decreased liver phosphoenolpyruvate carboxykinase (PEPCK) mRNA abundance. Dexamethasone attenuated the hypoglycemia and lactacidemia. Dexamethasone blunted the increase of GLUT1 mRNA abundance and increased the liver PEPCK mRNA abundance. Dexamethasone may be beneficial by promoting gluconeogenesis.
Deskriptorji     HYPOGLYCEMIA
DEXAMETHASONE
TUMOR NECROSIS FACTOR
SHOCK, SEPTIC
RATS, SPRAGUE-DAWLEY
ANIMALS, NEWBORN
BLOOD GLUCOSE
INSULIN
LACTATES
PHOSPHOENOLPYRUVATE CARBOXYLASE
RNA, MESSENGER
MONOSACCHARIDE TRANSPORT PROTEINS