Avtor/Urednik		Ransmayr, G; Benesch, H; Nowakowski, C; Maier, H; Hersh, LB
Naslov		Cholinergic neurons in the lateral vestibular nucleus are not affected in Parkinson's disease
Prevedeni naslov		Holinergični nevroni v lateralnem vestibularnem jedru niso prizadeti pri Parkinsonovi bolezni
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 65, št. Suppl 3
Leto izdaje		1996
Obseg		str. III-65-7
Jezik		eng
Abstrakt		The lateral vestibular nucleus (LVN, nucleus of Deiters) was examined in the brains of four patients without neuropsychiatric disorder and four patients with Parkinson's disease (PD). Immunohistochemistry with a polyclonal antibody to human choline acetyltransferase (ChAT) and routine histological stainings (hematoxylin-eosine, HE, and silver staining according to Palmgren) suggest that most or all perikarya in the LVN are cholinergic. The number of LVN perikarya was similar in the PD group and the controls. No Lewy bodies were found in perikarya of the LVN of PD brains (HE staining and immunohistochemistry with a polyclonal antibody to ubiquitin). Immunohistochemistry with a polyclonal antibody to tyrosine hydroxylase (TH) in four brains visualised structures suggestive of catecholaminergic terminals on LVN perikarya. Whether catecholaminergic afferences to LVN neurons are affected in PD needs to be clarified in consecutive studies.
Izvleček		Po smrti štirih bolnikov, ki niso imeli nevropsihiatričnih bolezni, in štirih bolnikov s Parkinsonovo boleznijo smo pregledali njihovo lateralno vestibularno jedro (LVN: Deitersovo jedtro). Imunohistokemične preiskave s poliklonalnim protitelesom za humano holinacetiltransferazo in rutinska histološka barvanja (hematoksilin-eozin in barvanje s srebrom po Palmgrenu) razkrivajo, da je večina perikarionov v LVN holinergičnih. Obe skupini sta imeli primerljivo število perikarionov v LVN. V LVN bolnikov s Parkinsonovo boleznijo ni bilo Lewijevih telesc (hematoksilineozin in imunohistokemija s poliklonalnim antitelesom na ubikvitin). Imunohistokemična preiskava s poliklonalnim protitelesom na tirozinhidroksilazo je v štirih možganih prikazala strukture, ki spominjajo na kateholaminergične končiče na perikarionih LVN. Nadalnje študije bodo potrebne za odgovor na vprašanje, če so pri Parkinsonovi bolezni prizadete kateholaminergične aference LVN.
Deskriptorji		PARKINSON DISEASE VESTIBULAR NUCLEI CHOLINERGIC FIBERS IMMUNOHISTOCHEMISTRY