Avtor/Urednik		Tang, WC; Pakula, Jeffrey L; Weil, Max Harry; Noč, Marko; Fukui, Michihiko; Bisera, Joe
Naslov		Adrenergic vasopressor agents and mechanical ventilation for the treatment of experimental septic shock
Tip		članek
Vir		Crit Care Med
Vol. in št.		Letnik 24, št. 1
Leto izdaje		1996
Obseg		str. 125-30
Jezik		eng
Abstrakt		OBJECTIVE: Vasopressor agents and mechanical ventilation are routine interventions for the treatment of sepsis complicated by hypotension. It was our hypothesis that such treatment singly or in combination increases the duration of survival. DESIGN: Prospective, randomized, controlled study. SETTING: University research laboratory. SUBJECTS: Thirty male Sprague-Dawley rats anesthetized with intraperitoneal injection of pentobarbital. INTERVENTIONS: Peritonitis was induced by cecal ligation and spillage of cecal contents into the abdominal cavity. The first phase of this study was performed on 15 spontaneously breathing Sprague-Dawley rats that were randomized to three groups of five animals each. One group received treatment with dopamine. The second group received norepinephrine. The third group received only the diluent as a placebo. Concentrations of the vasopressor agents were increased such that mean arterial pressure was maintained at approximately 80 percent of baseline values; the volumes infused were kept constant. For the second phase of this study, the grouping of animals and the techniques of study were identical, except that rats were mechanically ventilated. MEASUREMENTS AND MAIN RESULTS: Mean arterial pressure was best maintained with norepinephrine. However, no statistically significant differences in duration of survival, cardiac index, arterial blood lactate concentration, or arterial and venous PCO2 and PO2 values were identified between groups. With mechanical ventilation, survival was prolonged (p less th. .01). Survival was increased from an average of 291 mins to 342 mins with dopamine, from 257 mins to 352 mins in placebo controls, and from 280 mins to 329 mins with norepinephrine. Again, no significant differences in hemodynamic and blood gas measurements, or in the duration of survival between vasopressor-treated and control animals were documented.(trunc.)
Deskriptorji		ADRENERGIC ALPHA-AGONISTS DOPAMINE NOREPINEPHRINE RESPIRATION, ARTIFICIAL SHOCK, SEPTIC VASOCONSTRICTOR AGENTS BLOOD PRESSURE BODY TEMPERATURE COMBINED MODALITY THERAPY HEMODYNAMICS HEMOGLOBINS LACTATES PERITONITIS RATS RATS, SPRAGUE-DAWLEY