Avtor/Urednik		Meden-Vrtovec, Helena
Naslov		GH co-treatment for low responders in an IVF-ET programme
Tip		članek
Vir		Sing J Obstet Gynaecol
Vol. in št.		Letnik 27, št. 3
Leto izdaje		1996
Obseg		str. 55-60
Jezik		eng
Abstrakt		Objective: To evaluate ovarian responsiveness and clinical effects of GH co-treatment in clonidine negative patients in an IVF-ET programme according to an additional predictive factor, the efficacy index. Desing: Prospective randomized controlled study. Setting: Patients included in a university based assisted reproduction programme. Patients: The use of growth hormone (GH) for ovulation induction was studied in 29 clonidine negative patients. The patients were divided into two groups according to the results of the efficacy index which represents the ratio between estradiol (E2) concentration before human chorionic gonadotropin (hCG) administration and the total number of human menopausal gonadotropin (hMG) vials used in the previous cycle. Eleven patients with the efficacy index lower or equal to 0.05 were defined as low responders, 18 patients with the efficacy index higher than 0.05 represented normal responders. Interventions: The patients in the IVF-ET programme were stimulated with long protocol (GnRH-analogue, hMG and GH). At the time of follicular aspiration E2 and IGF1 concentrations in the serum and in the follicular fluid were determined. Main outcome measure: The determination of efficacy index, number of hMG ampules used for ovarian stimulation in conventional and GH co-treated cycles, E2 and IGF1 concentrations in the serum and in the follicular fluid at the time of oocyte retrieval, number of oocytes retrived and fertilized, number of embryos transferred and pregnancy rates. Results: Using GH co-treatment the efficacy index increased over 0.05 in 3(27%) of 11 low responders. In low responders the clinical results differed considerably: a significantly higher number of oocytes retrieved and embryos transferred were found in the GH co-treated cycle than in the previous one, despite the same hMG dose in the compared cycles. (Abstract truncated at 2000 characters.)
Deskriptorji		FERTILIZATION IN VITRO EMBRYO TRANSFER OVULATION INDUCTION SOMATOTROPIN SOMATOTROPIN-RELEASING HORMONE ESTRADIOL CLONIDINE INSULIN-LIKE GROWTH FACTOR I