Avtor/Urednik		Lešničar, Hotimir
Naslov		Zdravljenje lokalno napredovalih malignih obolenj s hkratnim obsevanjem in pregrevanjem
Prevedeni naslov		Combined hyperthermia and radiotherapy in treatment of advanced malignant tumors
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		1997
Obseg		str. 119
Jezik		slo
Abstrakt		Introduction of thermoradiotherapy into clinical practice is hindered, on the one hand, by technical problems in assuring sufficient heat supply into tumor tissue and, on the other, in insufficient knowledge on the role of the radiotherapy as the only measurable component of combined treatment. Interstitial circulating hot water hyperthermia, tested in animals and humans at our Institute, is one of the most accomplished methods of hyperthermia in vivo. Among the methods that have been used so far, it ensures a better homogeneity of heat distribution and is, at the same time, the only method allowing simultaneous irradiation. As to the basic technical specifications, a home-made microwave hyperthermia device has similar characteristics compared to any, commercially available and far more expensive device. Invasive temperature measurements allow the evaluation of both therapeutic and side effects'of thermotherapy. Regardless the method and efficiency of hyperthermia treatment, thermoradiotherapy is less effective in advanced tumors. This may reduce the value of thermoradiotherapy as the primary treatment method for advanced and inoperable tumors and at the same time suggests somewhat minor impact of direct cytotoxicity effects of hyperthermia . Efficient thermoradiotherapy may only be obtained by exceeding the a intratumoral temperature level of 42.5 degree. If immediate cytotoxic effects are not of such importance, it is possible that the mechanisms producing radiosensibilization depend upon the above temperature limit. Iradiation performed immediately after 60 minute hyperthermia treatment at temperatures exceeding 42.5 degree (Abstract truncated at 2000 character)
Deskriptorji		NEOPLASMS HYPERTHERMIA, INDUCED RABBITS SWINE SURVIVAL ANALYSIS TREATMENT OUTCOME