Avtor/Urednik		Rott, Tomaž
Naslov		Patološke spremembe pri aidsu
Prevedeni naslov		Pathology of aids
Tip		članek
Vir		Med Razgl
Vol. in št.		Letnik 36, št. Suppl
Leto izdaje		1997
Obseg		str. 243-58
Jezik		slo
Abstrakt		Patients with acquired immune deficiency syndrome (AIDS) frequently suffer and die from multiple localised and/or systemic opportunistic infections (caused by bacteria, viruses, mycoses, parasites), some malignomas (usually extranodal lymphomas and Kaposi sarcoma), and more or less characteristic pathologic changes in central nervous system, and in some other organs. Atrophy of lymphatic tissue in lymph nodes and spleen reflects defected cellular immunity. Similar pathology was found by autopsies in 20 patients deceased because of AIDS at the Institute of pathology. Opportunistic infections appeared in 85 %, multiple in 3/4 of patients, with relatively offen necrotic cytomegalic adrenalitis and rare Pneumocystis carinii pneumonia. Three patients suffered from extranodal B lymphoma, and another three from Kaposi sarcoma.
Izvleček		Bolniki z aidsom pogosto zbolevajo in umirajo zaradi večinoma multiplih lokaliziranih in/ali sistemskih oportunističnih okužb (ki jih povzročajo bakterije, virusi, glive, zajedalci), nekaterih malignih novotvorb (običajno ekstranodalnih limfomov in Kaposijevega sarkoma) in nekaterih bolj ali manj značilnih patoloških sprememb v osrednjem živčevju in drugih organih. Atrofija limfatičnega tkiva v bezgavkah in vranici odraža oslabljeno celično imunost. Podobne patološke spremembe so dokazali na Inštitutu za patologijo z avtopsijami 20 bolnikov, umrlih zaradi aidsa. Oportunistične okužbe so se pojavljale v 85 %, pri 3/4 bolnikov multiple, z relativno pogostim nekrozantnim citomegalnim vnetjem v nadledvičnicah in redko pljučnico zaradi okužbe s Pneumocystis carinii. Pri treh bolnikih je bil dokazan ekstranodalni B-limfom, pri drugih treh Kaposijev sarkom.
Deskriptorji		HIV INFECTIONS AIDS-RELATED OPPORTUNISTIC INFECTIONS AUTOPSY NEOPLASMS