Avtor/Urednik		Petrovec, Miroslav; Lotrič-Furlan, Stanka; Avšič-Županc, Tatjana; Strle, Franc; Brouqui, Philippe; Roux, Veronique; Dumler, Stephen J
Naslov		Human disease in Europe caused by granulocytic Ehrlichia species
Tip		članek
Vir		J Clin Microbiol
Vol. in št.		Letnik 35, št. 6
Leto izdaje		1997
Obseg		str. 1556-9
Jezik		eng
Abstrakt		Human granulocytic ehrlichiosis (EGE) was recently described in North America. It is caused by an Ehrlichia species closely related to Ehrlichia phagocytophila and Ehrlichia equi, recognized to infect mostly ruminants and horses, respecitively. The vector in North America is the tick Ixodes scapularis, which is also the vestor of the Lyme disease agent. Borrelia burgdorferi. Prevous serologic studies in patients with a diagnosis of Lyme borreliosis indicate that HGE may exist in Europe. We report the first documented case of HGE in Europe. The diagnosis was established by seeroconversion to E.equi and the HGE agent and by PCR with sequence analysis of the gene encoding the HGE agent 16S rRNA. Interestingly, the patient presented with a self-liited but moderately severe illness. Thus, European physicians need to be awere that HGE exists in Europe and that the diagnosis should be considered in febrile patients with tick bites in areas where Lyme disease is endemic.
Deskriptorji		EHRLICHIA EHRLICHIOSIS GRANULOCYTES ANTIBODIES, BACTERIAL DNA, BACTERIAL EHRLICHIA CHAFFEENSIS MIDDLE AGE POLYMERASE CHAIN REACTION RNA, BACTERIAL RNA, RIBOSOMAL, 16S SEQUENCE ANALYSIS, DNA SEQUENCE HOMOLOGY, NUCLEIC ACID