Avtor/Urednik		Jarm, Tomaž; Miklavčič, Damijan; Vodovnik, Lojze
Naslov		Bližnje-infrardeča spektroskopija - metoda za neinvazivno spremljanje prekrvljenosti in oksigenacije tkiv
Prevedeni naslov		Near-infrared spectroscopy - a method for noninvasive monitoring of perfusion and oxygenation in tissue
Tip		članek
Vir		Elektroteh Vestn
Vol. in št.		Letnik 64, št. 2-3
Leto izdaje		1997
Obseg		str. 98-105
Jezik		slo
Abstrakt		Ability to measure and monitor parameters of tissue oxygenation is of crucial importance in clinical environment for an obvious reason - these is no life without oxygen. Many different methods based on various physical principles have been applied to-date to help clinicians in detection and diagnosis of illness, in evaluation of therapy outcome or. in prediction of patient's response to treatments. oxygen is delivered to tissues with blood where it is carried in two forms; soluted in plasma and bound to hemoglobin. The equilibrium relationship of the two forms is described by the highly nonlinear dissociation curve (Figure 1). Available methods usually measure parameters which are in direct relationship either with partial pressure of oxygen (soluted oxygen) or hemoglobin saturation (hemoglobin-bound oxygen). Therefore their results are in general not interchangeable. The major drawbacks of most of standard methods are their invasiveness, unsuitability for routine continous measurement, price and sometimes bulk. Near-infrared spectroscopy (NIRS) is a relatively new tool which promises to be able to bypass effectively many of these problems. Furthermore, NIRS enables noninvasive monitoring of oxygenation status on different physiological levels, from oxigen content inblood by measuring concentrations of oxygenated and deoxygenated hemoglobin to metabolic activity of cells by measuring the redox state of mitochondrial enzymes cytochromes. The work of GA Millikan from 1942 isconsidered as the first use of optical spectroscopy of tissues. The first documented use of NIRS dates back to 1977, when oxygenation of brain and heart muscle of cats were measured by FF Joebsis. (Abstracts truncated at 2000 characters.)
Deskriptorji		OXYGEN CONSUMPTION SPECTROSCOPY, NEAR-INFRARED OXYGEN PARTIAL PRESSURE OXYHEMOGLOBINS