Avtor/Urednik		Miklavčič, Damijan; An, Dongjian; Belehradek, Jean Jr; Mir, Lluis M
Naslov		Host's immune response in electrotherapy of murine tumors by direct current
Tip		članek
Vir		Eur Cytokine Netw
Vol. in št.		Letnik 8, št. 3
Leto izdaje		1997
Obseg		str. 275-9
Jezik		eng
Abstrakt		Electrotherapy by low level direct current has been demonstrated to have antitumor effects in different murine tumor models and in clinics. Electrotherapy in "field" configuration, where electrodes are placed subcutaneously outside of the tumor in a way that tumor lies in between the electrodes, was performed in immunodeficient nude and immunocompetent mice. Electrotherapy was much more effective in immunocompetent mice based on the observed tumor growth retardation, thus demonstrating that antitumor effectiveness of electrotherapy greatly depends on host's immune response. Further experiments were conducted by combining electrotherapy with concomitant immunotherapy in order to potentiate the antitumor effect of electrotherapy. Immunotherapy consisted of local delivery of genetically engineered cells selected for IL-2 secretion. This combined treatment was much more effective than any of the treatments alone.
Deskriptorji		SARCOMA, EXPERIMENTAL ELECTRIC STIMULATION THERAPY MICE, INBRED C57BL MICE, NUDE HAMSTERS COMBINED MODALITY THERAPY IMMUNOTHERAPY TRANSFECTION INTERLEUKIN-2 CHO CELLS GENETIC ENGINEERING