Avtor/Urednik     Goto, Masakatsu; Yoshioka, Toyokazu; Young, Rita I; Battelino, Tadej; Anderson, Craig L; Zeller, Patrick W
Naslov     A sublethal dose of LPS to pregnant rats induces TNF-alpha tolerance in their 0-day-old offspring
Tip     članek
Vir     Am J Physiol
Vol. in št.     Letnik 273
Leto izdaje     1997
Obseg     str. R1158
Jezik     eng
Abstrakt     The newborn has high mortality in septic shock. Induction of endotoxin tolerance may prevent endotoxic shock in the newborn. The present study showed that a small dose of Salmonella enteritidis lipopolysaccharide (S. ent. LPS), Tc mutant Escherichia coli lipopolysaccharide (J5 LPS), or tumor necrosis factor-alpha (TNF-alpha) given to pregnant rats on the 19th day of gestation induced endotoxin tolerance in their 0-day-old offspring. S. ent. LPS or J5 LPS injected into pregnant rats increased plasma endotoxin-like activity in dams, although not in their fetuses, and increased plasma TNF-alpha concentration in both dams and their fetuses. The endotoxin-tolerant newborn rats ere also resistant to TNF-alpha. In those neborn rats, an LPS injection increased plasma TNF-alpha concentration and liver TNF-alpha mRNA abundance. These experiments showed that the endotoxin tolerance could be due to TNF-alpha tolerance. In conclusion, prenataltreatment of dams with a small dose of S. ent. LPS, J5 LPS, or TNF-alpha was beneficial in preventing endotoxic in the newborn.
Deskriptorji     TUMOR NECROSIS FACTOR
SHOCK, SEPTIC
LIPOPOLYSACCHARIDES
PRENATAL EXPOSURE DELAYED EFFECTS
ENDOTOXINS
RATS, SPRAGUE-DAWLEY
PREGNANCY, ANIMAL
ANIMALS, NEWBORN
ESCHERICHIA COLI
SALMONELLA ENTERITIDIS
RNA, MESSENGER
LIVER
TRANSCRIPTION, GENETIC