Avtor/Urednik | Goto, Masakatsu; Yoshioka, Toyokazu; Young, Rita I; Battelino, Tadej; Anderson, Craig L; Zeller, Patrick W | |
Naslov | A sublethal dose of LPS to pregnant rats induces TNF-alpha tolerance in their 0-day-old offspring | |
Tip | članek | |
Vir | Am J Physiol | |
Vol. in št. | Letnik 273 | |
Leto izdaje | 1997 | |
Obseg | str. R1158 | |
Jezik | eng | |
Abstrakt | The newborn has high mortality in septic shock. Induction of endotoxin tolerance may prevent endotoxic shock in the newborn. The present study showed that a small dose of Salmonella enteritidis lipopolysaccharide (S. ent. LPS), Tc mutant Escherichia coli lipopolysaccharide (J5 LPS), or tumor necrosis factor-alpha (TNF-alpha) given to pregnant rats on the 19th day of gestation induced endotoxin tolerance in their 0-day-old offspring. S. ent. LPS or J5 LPS injected into pregnant rats increased plasma endotoxin-like activity in dams, although not in their fetuses, and increased plasma TNF-alpha concentration in both dams and their fetuses. The endotoxin-tolerant newborn rats ere also resistant to TNF-alpha. In those neborn rats, an LPS injection increased plasma TNF-alpha concentration and liver TNF-alpha mRNA abundance. These experiments showed that the endotoxin tolerance could be due to TNF-alpha tolerance. In conclusion, prenataltreatment of dams with a small dose of S. ent. LPS, J5 LPS, or TNF-alpha was beneficial in preventing endotoxic in the newborn. | |
Deskriptorji | TUMOR NECROSIS FACTOR SHOCK, SEPTIC LIPOPOLYSACCHARIDES PRENATAL EXPOSURE DELAYED EFFECTS ENDOTOXINS RATS, SPRAGUE-DAWLEY PREGNANCY, ANIMAL ANIMALS, NEWBORN ESCHERICHIA COLI SALMONELLA ENTERITIDIS RNA, MESSENGER LIVER TRANSCRIPTION, GENETIC |