Avtor/Urednik		Mermolja, Milivoj; Kern, Izidor; Terčelj, Marjeta; Jereb, Marjan
Naslov		Cytology of mediastinal tumors
Prevedeni naslov		Citologija mediastinalnih tumorjev
Tip		članek
Vir		Radiol Oncol
Vol. in št.		Letnik 31, št. 4
Leto izdaje		1997
Obseg		str. 380-3
Jezik		eng
Abstrakt		Our experience with cytological examinations of tumorous mediastinal lesions is evaluated. A group of 117 patients with mediastinal tumor have been included into the study. Among them carcinomas prevailed (60,7%), followed by lymphomas (18,8%), other tumors (15.4%) and thymic neoplasms (5.1%). Malignant or suspicious cells were found in 77.4% of patients with carcinoma. The cells indicating a possibility of non-Hodgkin's lymphoma were found in 9 out of 14 patients. In 5 out of 6 thymic neoplasms the cytological pattern was consistent with the diagnosis of thymic neoplasm. One case of thymoma was cytologically falsely diagnosed as malignant lymphoma. One case of neurofibroma was falsely diagnosed as adenocarcinoma. The sensitivity of cytological examinations was 67.5%. If 18 patients with diagnostically unsatisfactory material were excluded from the analysis, the sensitivity would increase to 80.8%. Owing to the wide variety of primary and metastatic tumors that can occur in the mediastinum, apart from the routine cytological techniques, additional staining methods should be used. For final cytological diagnosis the integration of cytological findings with clinical and radiological data is often required. Owing to the characteristics of the obtained material and biological behaviour of some mediastinal tumors, some tumors cannot be definitively diagnosed by cytological examinations alone.
Izvleček		Avtorji predstavijo izkušnje Kliničnega oddelka za pljučne bolezni in alergična stanja Golnik s citološkimi pregledi mediastinalnih tumorjev. V retrospektivno študijo je bilo vključenih 117 bolnikov z mediastinalnim tumorjem. Najpogostejši so bili karcinomi (60,7%0, sledijo limfomi (18,8%), drugi tumorji (15,4%), in timične neoplazme (5,1%). Maligne ali sunljive celice so našli pri 77,4% bolnikov s karcinomom. Celice, ki so dopuščale možnost ne-Hodgkinovega limfoma, so našli pri 9 od 14 bolnikov. Pri 5 od 6 primerov timičnih neplazem je bila citološka slika skladna z diagnozo timične neoplazme. En primer timoma je bil citološko napačno opredeljen kot maligni limfom, en primer neurofibroma pa je bil napačno opredeljen kot adenokarcinom. Senzitivnost citoloških pregledov je bila 67,5%. Če bi 18 bolnikov, pri katerih dobljeni material ni bil ustrezen, izključili iz analize, bi senzitivnost zrasla na 80,8%. Ker so primarni in metastatski tumorji, ki se pojavljajo v mediastinumu zelo raznoliki, so za njihovo opredelitev poleg rutinskih citoloških tehnik potrebne tudi dodatne metode barvanja. Za končno citološko diagnozo je nujno poznati tudi klinične podatke in podatke slikovnih diagnostičnih metod. Glede na značilnosti dobljenjega materiala in biološko obnašanje nekaterih mediastinalnih tumorjev vseh ni možno definitivno opredeliti na osnovi citološkega pregleda.
Deskriptorji		MEDIASTINAL NEOPLASMS BIOPSY, NEEDLE