| Avtor/Urednik | Falnoga, Ingrid | |
| Naslov | Proučevanje mehanizmov kopičenja živega srebra s pomočjo avtopitčnih vzorcev | |
| Tip | monografija | |
| Kraj izdaje | Ljubljana | |
| Založnik | Fakulteta za farmacijo | |
| Leto izdaje | 1995 | |
| Obseg | str. 97 | |
| Jezik | slo | |
| Abstrakt | The concentrations of mercury (Hg) and selenium (Se) were followed in autopsy samples from the following three groups: l. a control group with no known exposure to mercury from the living environment, the Idrijan population exposed to elevated concentrations in their living environment, and 3. Idrija mercury mine workers. Because the general population is obviously continuously exposed to cadmium (Cd) from food, in some autopsy samples the concentrations of cadmium were evaluated. In endocrine glands (pituitary, thyroid), kidneys and brain tissue (dentate nucleus) the accumulation and retention of mercury and selenium was confirmed. Selenium coaccumulation was notable only in samples where the mercury concentrations were > 2 micro g/g. In these cases the molar ratio Hg/Se was close to one or higher. In all organs and tissues of the control group and the Idrijan population the average values of cadmium exceeded the average values of mercury. In view of the association of selenium with mercury, and the higher Cd levels, it is debatable which element is the more hazardous for the general population as concern neurotoxicity. Accumulation of mercury was investigated with using autopsy samples from active and retired Idrija mercury mine workers and also using of samples from experimental animals (rats) continuously exposed to elemental mercury vapour in the mine. We were interested in the cellular distribution of accumulated (retained) mercury with selenium, and the presence of metallothionein (MT)-like proteins, Hg-thioneins. Both phenomena, coaccumulation of selenium and the binding of mercury to MT are proposed to have important roles in storing Hg in biologically inert forms. From human and animal thyroid cytosol, MT-like proteins were isolated and partially characterised (Hg,Cd,Cu,Zn-thionein, Pb,Cd,Cu,Zn-thionein, Cd,Cu,Zn-thionein, Hg-thionein). (Abstract truncated at 2000 characters) | |
| Deskriptorji | OCCUPATIONAL EXPOSURE ENVIRONMENTAL EXPOSURE MERCURY SELENIUM METALLOTHIONEIN RATS AUTOPSY ZINC COPPER CADMIUM IODINE BROMINE IRON |