Avtor/Urednik		Osmak, Maja
Naslov		Molecular alterations induced in drug-resistant cells
Prevedeni naslov		Molecularne spremembe v celicah rezistentnih na citostatike
Tip		članek
Vir		Radiol Oncol
Vol. in št.		Letnik 32, št. 1
Leto izdaje		1998
Obseg		str. 19-33
Jezik		eng
Abstrakt		The major obstacle to the ultimate success in cancer therapy is the ability of tumor cells to develop resistance to anticancer drugs. Several molecular mechanisms have been suggested to be involved in drugresistance: a) decrease in the intracellular drug accumulation (increased activity of membrane transporters such as P-glycoprotein or multidrug-resistance-associated protein), b) changes in intracellular detoxification system (increased concentrations of glutathione or metallothioneins, or increased activity of related enzymed), c) alteration in nuclear enzymes (enhanced DNA repair and/or better tolerance of DNA damage, decreased acitivty of topoisomerases), d) altered expression of oncogenes (inducing increased level of protective molecules in cells or the inhibition of apoptosis). Drug resistance is a multifactorial phenomenon. The complexity of molecular alterations in drug-resistant cells is and will stay the main problem for the successful treatment of cancer.
Deskriptorji		DRUG RESISTANCE ANTINEOPLASTIC AGENTS DRUG RESISTANCE, NEOPLASM GLUTATHIONE GLUTATHIONE TRANSFERASES GLUTATHIONE PEROXIDASE METALLOTHIONEIN GENE AMPLIFICATION DNA REPAIR DNA TOPOISOMERASE