Avtor/Urednik		Rapozzi, Valentina; Perissin, Laura; Zorzet, Sonia; Comelli, Marina; Mavelli, Irene; Šentjurc, Marjeta; Pregelj, Alja; Schara, Milan; Giraldi, Tullio
Naslov		Bone marrow toxicity and antitumor action of adriamycin in relation to the antioxidant effects of melatonin
Prevedeni naslov		Antioksidativni efekt melatonina in njegov vpliv na mielotoksičnost in protitumorsko delovanje adriamicina
Tip		članek
Vir		Radiol Oncol
Vol. in št.		Letnik 32, št. 1
Leto izdaje		1998
Obseg		str. 95-102
Jezik		eng
Abstrakt		Melatonin has been reported to possess numerous properties, including antioxidant effects. Some antitumor drugs, such as anthracyclines, display a pro-oxidant activity which is help responsible for their toxicity to normal tissues of the host. The aim of this work was, therefore, to preliminarily examine the effects of melatonin on the bone marrow toxicity caused by the treatment with adriamycin in CBA mice bearing TLX5 lymphoma. After a single treatment with adriamycin (28-40 mg/kg i.v.), the administration of a single pharmacological dose of melatonin (10 mg/kg s.c.) recuded the acute mortaility of the hosts from 9/16 to 2/16. The antitumor action of adriamycin, consisting in the increase in survival time of animals which were not affected by the acute toxicity of the drug, was not reduced by melatonin. Melatonin also attenuated the reduction in the number of bone marrow GB-CFU caused by adiamycin, and significantly restored the reduced and total glutathione levels. Moreover, the use of Fenton reaction and free radical determination via spin trapping, show that melatonin acts as a direct free radical scavenger. The data reported indicate that melatonin attenuates the bone marrow toxicity of adriamycin with a mechanism consistent with its antioxidant properties.
Deskriptorji		LYMPHOMA DOXORUBICIN BONE MARROW MELATONIN MICE