Avtor/Urednik		Fras, Zlatko
Naslov		Polimetabolni sindrom in razvoj ateroskleroze
Prevedeni naslov		Polymetabolic syndrome and the development of atherosclerosis
Tip		članek
Vir		Med Razgl
Vol. in št.		Letnik 37, št. Suppl 3
Leto izdaje		1998
Obseg		str. 35-46
Jezik		slo
Abstrakt		(Poly)metabolic syndrome X (insulin resistance syndrome) represents the concept of reduced tissue insulin sensitivity associated with or causing several harmful metabolic conditions. It comprises major cardiovascular risk factors including hypertension, dyslipidemia, non-insulin dependent diabetes mellitus (or at least impaired glucose intolerance), visceral obesity and many other threatening conditions which are predisposing for the development of atherosclerosis (e.g. hyperuricemia and hypofibrinolysis). The polyvalent syndrome described is based on a great deal of positive evidences from prospective and cross-sectional epidemiological studies performed during the last two decades. The introduction of the concept of a common denominator for these important disorders of modern society has many potentially advantageous clinical implications. It seems that the most important is the recommendation for integrative treatment of patients with any one of the disorders in question.
Izvleček		(Poli)metabolni sindrom X (sindrom inzulinske rezistence) predstavlja koncept odpornosti tkiv na delovanje inzulina kot bolezenske nepravilnosti, ki je verjetno vzročno povezana s številnimi poglavitnimi dejavniki tveganja za nastanek bolezni srca in žilja. Med te sodijo hipertenzija, motena presnova telesnih maščob, od inzulina neodvisna sladkorna bolezen (ali vsaj motena toleranca za glukozo), androidni tip debelosti in nekateri drugi, v zadnjem času odkriti dejavniki ogroženosti za nastanek in napredovanje ateroskleroze (npr. hiperurikemija in stanje zmanjšane fibrinolitične aktivnosti krvi). Obstoj tega polivalentnega sindroma je podprt s številnimi izsledki prospektivnih in presečnih epidemioloških študij zadnjih dvajsetih let. Koncept, ki temelji na skupnem imenovalcu kroničnih bolezni moderne dobe, ima veliko potencialno koristno klinično uporabnost. Najpomembnejši se zdi predlog nujne celostne obravnave bolnikov s katerokoli od bolezni, ki jih sindrom zaobsega.
Deskriptorji		INSULIN RESISTANCE ATHEROSCLEROSIS HYPERINSULINEMIA RISK FACTORS DIABETES MELLITUS