Avtor/Urednik		Zidar, Nina; Avguštin-Čavić, Marija; Kenda, Rajko B; Koselj, Mira; Ferluga, Dušan
Naslov		Effect of intrauterine growth retardation on the clinical course and prognosis of IgA glomerulonephritis in children
Tip		članek
Vir		Nephron
Vol. in št.		Letnik 79, št. 1
Leto izdaje		1998
Obseg		str. 28-32
Jezik		eng
Abstrakt		Intrauterine growth retardation (IUGR) resulting in a reduced number of nephrons is one of the nonimmune mechanisms that have been recently proposed as contributing to the progression of renal diseases. The purpose of our study was to determine whether IUGR has any effect on the clinical course and prognosis of IgA glomerulonephritis (IgA GN) in children. Fifty children with biopsy-proven IgA GN, who were followed for at least 3 yers, were included. Six of the 50 children (12%) had signs of IUGR at birth, defined as birth weight below the 10th percentile for gestational age. There were no significant differences in initial clinical presentation between children with IUGR and those without IUGR. However, in kidney biopsy specimens, we found a significantly higher mean percentage of sclerotic glomeruli in children with IUGR than in those without IUGR (33 vs. 13%, p < 0.015). At the end of the follow-up period, we observed a significantly higher incidence of arterial hypertension in children with IUGR than inthose without IUGR (50 vs. 11%, p<0.05). Other differecnes between the two groups of children were not statistically significant. In conclusion, our study demonstrated an increased risk of the development of arterial hypertension and glomerulosclerosis inchildren with IgA GN who had suffered from IUGR with a birth weight below the 10th percentile for gestational age. IUGR may therefore help to identify early in the course of IgA GN those children who are at higher risk of an unfavorable course.
Deskriptorji		FETAL GROWTH RETARDATION NEPHROSIS, LIPOID CHILD ADOLESCENCE PREGNANCY ADRENAL CORTEX HORMONES PROGNOSIS RECURRENCE RESPIRATORY TRACT INFECTIONS