Avtor/Urednik		Sketelj, J; Bajrović, F
Naslov		Nerve regeneration and collateral sprouting
Tip		članek
Vir		In: Stalberg EV, de Weerd AW, Zidar J, editors. ECCN 98. 9th European congress of clinical neurophysiology; 1998 Jun 4-7; Ljubljana. Bologna: Monduzzi Editore,
Leto izdaje		1998
Obseg		str. 29-32
Jezik		eng
Abstrakt		Collateral sprouting is an outgrowth of additional terminals from uninjured axons in response to partial denervation of target tissue. Sprouting of cutanous axonsis probably induced by increased NGF availability in the denervated skin. Prior collateral sprouting may, therefore, enhance regeneration of these axons after subsequent lesion. We found that elongation rate of sensory axons regenerating after crush injury was not changed after prior collateral sprouting. If the sensory axons regenerated after crush in the absence of Schwann cell support in the distal nerve segment, their elongation rate decreased by 30-40%. In this case, however, prior sprouting was able to compensate for the loss of cell support, and restore elongaton rate of regenerating axons back tonormal. The effect was not observed either after conditiong lesion or after a predegenerated nerve graft had been sutured alongside the acellular nerve segment.
Deskriptorji		NERVE REGENERATION NEURONS AXONS SCIATIC NERVE NERVE CRUSH RATS