Avtor/Urednik		Travis, James; Potempa, Jan
Naslov		The role of bacterial proteinases in periodontal disease
Prevedeni naslov		Vloga bakterijskih proteinaz pri parodontalni bolezni
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 67, št. Suppl 2
Leto izdaje		1998
Obseg		str. II-25-7
Jezik		eng
Abstrakt		The organism Porphyromonas gingivalis has been found to be a major factor in the development od periodontitis. This bacterium secretes significant quantities of proteinases which can specifically activate the kallikrein/kinin, coagulation, and complement cascade systems to produce both a source of host nutrients and host proteinases at or near the site of infection. It is through utilization of the host-defense system to its own benefit that P. gingivalis manages to grow and proliferative throughout the gingival tissues, while causing the tissue damage associated with periodontal disease. Therefore, a suitable target for therapy are proteinases which activate the systems described earlier, rather than bacterial pathogens themselves. Instead of the use of antibiotics, the data from the reviewed literature suggest that either synthetic proteinase inhibitors and/or vaccines directed against proteinases from these organisms might be an alternative for therapy.
Izvleček		Porphyromonas gingivalis (P.g.) je ena od glavnih bakterij v zobnih oblogah, ki sodeluje pri začetku razvoja parodontitisa odraslih ljudi. Porphyromonas gingivalis ima mnogo mehanizmov, s katerimi se brani pred obzobnimi reakcijami organizma. Med temi mehanizmi so sposobnost obrambe pred oksidanti in možnost sproščanja proteolitičnih encimov, ki P.g. omogočajo rast in proliferacijo. Članek obravnava: vlogo dveh specifičnih cisteinskih proteinaz gingipain R in gingipain K, ki jih sprošča P.g. Gingipain R sodelujejo pri disregulaciji strjevanja krvi in sistemov kalikrein/kinina in komplementa, gingipain K pa ima sposobnost razgradnje fibrinogena. Avtorja predstavljata hipotezo, da P.g. s sproščanjem obeh gingipainov povzroči aktivacijo sistemov kalikrein/kinina in komplementa ter nastanek edema, krvavitev in povečanega izločanja gingivalne tekočine in obzobnih tkivih. Avtorja predpostavljata, da bi s sintetičnimi proteinaznimi inhibitorji ali cepivom proti gingipainoma lahko učinkovito zdravili parodontalno bolezen.
Deskriptorji		GINGIVITIS PORPHYROMONAS GINGIVALIS PEPTIDE PEPTIDOHYDROLASES