Avtor/Urednik		Kramar, Barbara; Matičič, Mojca; Tomažič, Janez; Vidmar, Ludvik; Skalerič, Uroš
Naslov		Prevalence of oral pathology and periodontal disease in HIV-1 infected patients in Slovenia
Prevedeni naslov		Pogostnost bolezni ustne sluznice in obzobnih tkiv pri pacientih, okuženih s HIV-1, v Sloveniji
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 67, št. Suppl 2
Leto izdaje		1998
Obseg		str. II-79-82
Jezik		eng
Abstrakt		Background. prevalence of oral pathology and periodontal disease is frequent in HIV infected patients. In this study we examined the oral mucosa and periodontal tissues in HIV-1 infected patients in Slovenia, and compared the oral findings to the progression of HIV-1 infection. Patients and methods. We examined 35 HIV-1 infected patients (27 males and 8 females; age: 19-56 years; mean: 38.8 years), and 35 gender and age matched seronegative control subjects. Oral mucosa lesions were assessed by an oral clinical examination. Plaque deposits and periodontal tissues were evaluated by the established clinical parameters: Plaque Index (PI), Gingival Index (GI), probing depth (PD) and epithelial attachment loss (EAL). The stage of HIV-1 infection was assessed by the number of CD4+ T-lymphocytes and the number of HIV-1 RNA- copies/ml in the patients sera. A statistical analysis was performed by the Student's t-test and the Pearson's correlation coefficient. Results. In 10 patients (28.6%) we found clinical manifestations of pseudomembranous oral candidiasis. Ten patients (28.6%) also showed the manifestation of hairy leukoplakia on the lateral margins of the tongue. No oral mucosa lesions were observed in the control group. HIV-1 infected patients with observed in the control group. HIV-1 infected patients with oral candidiasis and hairy leukoplakia hada a significantly lower number (t = 2.22, P < 0.05; t = 2.23, P < 0.05, respectively) of CD4+ T-lymphocytes, and a non-significantly higher number of HIV-1 RNA copies/ml in the sera comparing to the values found in HIV-1 infect patients without oral candidiasis and hairy leukoplakia.(Abstract truncated at 2000 characters.)
Izvleček		Izhodišča. Bolezni ustne sluznice in obzobnih tkiv so pogostne pri pacientih, okuženih s HIV. Med raziskavo smo pregledali stanje ustne sluznice in obzobnih tkiv pri pacientih v Sloveniji, okuženih s HIV-1, in stanje v ustni votlini primerjali s stopnjo napredovanja okužbe s HIV-1. Pacienti in metode. Pregledali smo 35 pacientov, okuženih s HIV-1 (27 moških in 8 žensk, starih 19-56 let in s povprečno starostjo 38,8 let) ter 35 po spolu in starosti primerljivih seronegativnih kontrolnih oseb. Spremembe na ustni sluznici smo ocenili s kliničnim pregledom. Količino zobnih oblok in stanje obzobnih tkiv smo določili z ustaljenimi kliničnimi parametri kot so: indeks plaka (PI), gingivalni indeks (GI), globina sondiranja in izguba epitelijskega prirastišča. Stopnjo razvoja okužbe s HIV-1 smo pri pacientih ocenili s številom CD4e+ T-limfocitov in številom kopij HIV-1 RNA/ml v serumu. Rezultate smo statistično ovrednotili s Studentovim t-testom in Pearsonovim korelacijskim koeficientom. Rezultati. Pri 10 pacientih (28%) smo v ustni votlini ugotovili znake psevdomembranozne kandidaze in prav tako pri 10 pacientih (28,6%) znake lasaste levkoplakije na lateralnem robu jezika. Kontrolna skupina ljudi ni imela znakov bolezni ustne sluznice. pri pacientih, okuženih s HIV-1, ki so imeli oralno kandidiazo in lasasto levkoplakijo, smo izmerili značilno nižje vrednosti (t = 2,22, P < 0,05; t = 2,21, P < 0,05) Cd4+ T-limfocitov in neznačilno višje število kopij HIV-1 RNA/ml v serumu v primerjavi z vrednostmi pri pacientih, okuženih s HIV-1 bre oralne kandidiaze in lasaste levkoplakije.(Izvleček prekinjen pri 2000 znakih.)
Deskriptorji		ACQUIRED IMMUNODEFICIENCY SYNDROME CANDIDIASIS, ORAL LEUKOPLAKIA, HAIRY PERIODONTAL DISEASES CD4-POSITIVE T-LYMPHOCYTES SLOVENIA