Avtor/Urednik     Iglič, Aleš; Kralj-Iglič, Veronika; Haegerstrand, Henry
Naslov     Amphiphile induced echinocyte-spheroechinocyte transformation of red blood cell shape
Tip     članek
Vir     Eur Biophys J
Vol. in št.     Letnik 27
Leto izdaje     1998
Obseg     str. 335-9
Jezik     eng
Abstrakt     A possible physical explanation of the echinocyte-spheroechinocyte red blood cell (RBC) shape transformation induced by the intercalation of amphiphilic molecules into the outer layer of the RBC plasma membrane bilayer is given. The stable RBC shape is determined by the minimization of the membrane elastic energy, consisting of the bilayer bending energy, the bilayer relative streching energy and the skeleton shear elastic energy. It is hown that for a given relative cell volume the calculated number of echinocyte spicula increases while their size decreases as the number of the intercalated amphiphilic molecules in the outer layer of the cell membrane bilayer is increased, which is in agreement with experimental observations. Further, it is shown that the equilibrium difference between the outer and the inner membrane leaflet areas of the stable RBC shapes increases if the amount of the intercalated amphiphiles is increased, thereby verifying theoretically the original bilayer couple hypothesis of Sheetz and Singer (1974) and Evans (1974).
Deskriptorji     ERYTHROCYTES
ERYTHROCYTE MEMBRANE
CELL SIZE
ELASTICITY
ERYTHROCYTES, ABNORMAL
INTERCALATING AGENTS
LIPID BILAYERS
MODELS, BIOLOGICAL
SPHEROCYTES
THERMODYNAMICS