Avtor/Urednik		Grobovšek-Opara, Sonja
Naslov		Vpliv alkoholnih pijač, prehrane in zdravil na tveganje zbolevanja za jetrno cirozo
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		1998
Obseg		str. 110
Jezik		slo
Abstrakt		Our research is a case-control study where the influence of alcohol drinking, diet and drugs consumption on the risk of liver cirrhosis occurrence in Slovenia was investigated. 182 in-patients were included in the study, who were for the first time treated for liver cirrhosis on the internal disease wards of the Slovenian hospitals in the period between January to July l995. Liver cirrhosis was diagnosed on the basis of clinical status, adequate laboratory tests and liver ultrasound examination. Control persons were taken fiom the Population Registry of the Statistical Offce of the Republic of Slovenia, and they were adjusted to the patients according to gender, age and dwelling place. We searched for two control persons for each patient. The data were gathered in personal interviews. Patients were interviewed in hospitals, and control persons at their homes. In the statistical analysis of data the univariate and multivariate conditional logistic regression was used. In the multivariate models additionally to alcohol, food, nutrients and hepatotoxic drugs, the education status, marital status and the entire calories were included as well, while in the final models the body mass index was also added. We found out that consuming alcohol and hepatotoxic drugs increased the risk for liver cirrhosis, while the appropriate diet had a protective effect. The association between the alcohol drinking and liver cirrhosis depends on the daily amount of consumed alcohol and the duration of drinking; the risk for liver cirrhosis was growing with the increasing cumulative amount of alcohol. Relative risks were high, confirming the causal relationship between alcohol drinking and liver cirrhosis occurrence. Alcohol drinkers had 7,3-times greater risk for liver cirrhosis appearance in comparison with non-drinkers. (trunc. at 2000 chars)
Deskriptorji		LIVER CIRRHOSIS LIVER CIRRHOSIS, ALCOHOLIC RISK FACTORS LIVER ALCOHOL DRINKING DIET ACETAMINOPHEN SEX FACTORS MILK VITAMINS CASE-CONTROL STUDIES