Avtor/Urednik		Turel, Matjaž
Naslov		Cirkadiani ritmovi eozinofilnog kationskog proteina u bolesnika s astmom liječenih ciklosporinom
Tip		monografija
Kraj izdaje		Zagreb
Založnik		Sveučilište u Zagrebu, Medicinski fakultet
Leto izdaje		1996
Obseg		str. 60
Jezik		cro
Abstrakt		Asthma is a chronic inflammatory disorder of the airways in which many cells play a role, including eoisinophils (EOS). Corticosteroids are currently the most effective anti-inflammatory drugs for the treatment of asthma. Cyclosporine A, common drug in the transplantation treatment is an immunosupresive drug with potentially beneficial effect on inflammated airways. In the steroid dependent (SDA) is the main goal to reduce steroid side effects and in the steroid resistant asthmatics (SRA) to find other effectively antiinflammatory drug. The main goal of this study was to find out if low doses (2mg/kg/day) CyA in a week treatment has an influence on serum ECP, blood count of EOS and airway obstruction. We treated one week 12 SDA with Cyth (group A), 8 asthmatic (the first control group) without regularly use of the systemic corticosteroids with 40 mg methylprednisolon (MDA) daily (group B). We have performed the same measurements in 8 healthy atopics (the second control group) without asthma history (group C). In the groups A and B we have collected blood samples every four hours the day before and the last day of the treatment. We performed measurements in the group C only one day. In the group A we registered at the same times peak experatory flow rate (PEFR). CyA did not significantly change circadian rhythms of the serum ECP, EOS blood count and PEFR. There were no CyA side effects registered. In the group B we found (at 4 PM, 8 PM and 4AM) statistically significant (p<0.05) differences in the serum ECP concentration and in the EOS blood count (all samples) before and after the treatment with MDA. We conclude that short treatment with low doses CyA did not have an important influence on the serum ECP concentrations, EOS blood count and airway obstruction circadian rhythms. It is possible, that the low doses CyA not important inhibit, the EOS proliferation and activation (mainly interlevkin 5) responsible, limphokines production and release.
Deskriptorji		ASTHMA CYCLOSPORINE CIRCADIAN RHYTHM EOSINOPHILS BLOOD PROTEINS