Avtor/Urednik		Koporc, Andrej; Kotnik, Tadej; Miklavčič, Damijan
Naslov		Numerično modeliranje elektroporacije celične membrane
Prevedeni naslov		Numerical modeling of cell membrane electroporation
Tip		članek
Vir		In: Zajc B, editor. Zbornik 7. elektrotehniške in računalniške konference ERK'98. Zvezek B. Računalništvo in informatika, umetna inteligenca, robotika, razpoznavanje vzorcev, biomedicinska tehnika, močnostna elektrotehnika, didaktika, študentski članki; 1998 sep 24-26; Portorož. Ljubljana: Slovenska sekcija IEEE,
Leto izdaje		1998
Obseg		str. 387-90
Jezik		slo
Abstrakt		Electroporation is associated with increased membrane permeability and conductivity. This paper deals with numerical modeling of the effect of electroporation on the transmembrane voltage. As the field intensity increases, the threshold value of transmembrane voltage for electroporation is first reached at the apical area facing the positive electrode. The model shows that the occurence of a pore, or a porous area, in this region leads to an almost doubled voltage at the diametrically opposite side of the membrane. The amplitude of voltage induced on the nonporated side is then analyzed as a function of the size of the pore/porated area, and the conductivity of the pore/porated area. If the above-threshold value of transmembrane voltage would suffice for electroporation, increase in transmembrane voltage on the non-porated side should results in an intensive electroporation of that side. However, experimental studies rarely report bilateral cases of poration. Commonly used pulse durations exceed the time constant of electroporation by one or more orders of magnitude. A more plausible explanation is offered by the asymmetric structure of the membrane.
Deskriptorji		ELECTROPORATION MEMBRANE POTENTIALS CELL MEMBRANE PERMEABILITY NUMERICAL ANALYSIS, COMPUTER-ASSISTED